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Automated Gel Permeation Chromatography (GPC) Cleanup

Size-exclusion cleanup that strips matrix from food and environmental extracts.

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GPC1000 automated gel permeation chromatography cleanup system

Organic Sample Preparation · 3 models

Gel permeation chromatography cleanup separates a crude extract by molecular size, collecting the fraction that contains the target analytes while large matrix molecules and small interfering species go elsewhere. Removing that matrix before instrumental analysis protects columns and detectors, lowers maintenance, and improves signal quality at low concentrations. LabTech's GPC systems cover the fully automated GPC1000 and the semi-automatic GPC600 UP and GPC600 mini, which share column chemistry and collection hardware and differ in how much of the sequence runs without an operator.

Protects the analytical column

Lipids, polymers and other macromolecular matrix are diverted before they reach the analytical column, which extends column life.

Column ready to run

Stainless steel columns are supplied packed, removing manual packing time and the solvent that column preparation consumes.

Real-time elution monitoring

A variable wavelength UV detector shows the eluate continuously, so fraction windows can be set during method development.

No-transfer collection

Collection racks accept vials and bottles that fit parallel concentration and rotary evaporation, avoiding a transfer step.

Models

Choose the configuration.

All three use a stainless steel GPC column that arrives packed, so there is no manual column preparation and less solvent is consumed during set-up. A dual-plunger pump with damper holds a steady flow, and a variable wavelength UV detector shows what is eluting in real time, which shortens method development. Collection runs through a three-dimensional mechanical arm that pierces septa, and the racks hand samples directly to parallel concentration or rotary evaporation without a transfer step.

GPC1000

Fully automated gel permeation chromatography cleanup system

GPC1000 performs the whole cleanup sequence on its own: sample injection, separation on the GPC column, and collection of the target fraction. A three-dimensional mechanical platform handles loading and collection through septa, and the loading and collection needles are washed inside and out. It fits laboratories running long series of food, environmental or agricultural extracts where operator time is the constraint.

Automates injection, separation and target fraction collection in one sequence.
Standard stainless steel GPC column is supplied packed, with no manual packing.
Dual-plunger precision pump with damper holds flow steady and accurate.
Variable wavelength UV detector tracks the eluate during method development.
Complete loading mode injects any sample volume up to 10 mL.
Real-time pressure monitoring with overpressure and pressure-release alarms.
Modular design allows additional collectors to be added as sample numbers grow.

Injection volume	Complete loading of any volume up to 10 mL
Pump	Dual-plunger precision pump with damper
Detection	Variable wavelength UV
Column	Stainless steel GPC column, supplied packed
Pressure	Real-time monitoring with overpressure and pressure-release alarm
Automation	Automatic injection, separation and fraction collection

GPC600 UP

Semi-automatic gel permeation chromatography cleanup system

GPC600 UP takes manual injection through an injection valve, then purifies automatically on a high-efficiency stainless steel column and collects target fractions in batches. The column is patented, and collection is by a three-dimensional robotic arm that pierces septa to limit solvent loss. Collection bottles connect to parallel concentration or rotary evaporation, so the extract moves on without being transferred.

Manual injection, then automatic purification and batch fraction collection.
Patented stainless steel purification column for reproducible cleanup.
High-precision dual-plunger pump with variable wavelength UV detector.
Three-dimensional robotic arm collects across multiple positions continuously.
Septum piercing keeps collection closed and limits organic solvent evaporation.
Collection needle is cleaned inside and outside automatically.
Sample rack pairs with parallel concentration products, so no sample transfer.

Injection	Manual injection into the injection valve
Column	Patented stainless steel purification column
Pump	High-precision dual-plunger pump
Detection	Variable wavelength UV
Collection	Three-dimensional robotic arm, multi-position automatic collection

GPC600 mini

Compact semi-automatic gel permeation chromatography cleanup system

GPC600 mini is the compact semi-automatic system: manual injection into the valve, automatic purification on a high-efficiency stainless steel column, and automatic collection of the target fraction. It provides two rotary evaporator bottle positions that alternate, and the bottles connect directly to rotary evaporation. The modular frame can be upgraded to GPC600 UP or GPC1000 as workload grows.

Manual injection with automatic purification and fraction collection.
Two rotary evaporator bottle positions are used alternately.
Collection bottles connect to rotary evaporation without sample transfer.
Modular design can be upgraded to GPC600 UP or GPC1000.
High-efficiency stainless steel purification column for reliable cleanup.
Compact bench format for laboratories starting GPC cleanup work.
Collection bottles also pair with parallel concentration products.

Injection	Manual injection into the injection valve
Collection	Two rotary evaporator bottle positions, alternating
Upgrade path	GPC600 UP or GPC1000

Full specifications for other configurations, voltages and options are available on request.

The range

Configurations and accessories.

GPC600 UP semi-automated GPC cleanup system

GPC600 mini semi-automated GPC cleanup system

Applications

Where this range is used.

Fat and lipid removal from food extracts before GC-MS
Pesticide residue cleanup in fruit, vegetable and grain extracts
Soil, sediment and sludge extracts before PAH or PCB analysis
Plant and agricultural product extracts with a heavy matrix load
Polymer and plastics extracts where oligomers interfere with detection

Food & Agriculture →

Questions

Before you buy.

What does GPC cleanup remove from a sample extract?

Gel permeation chromatography separates molecules by size, so the column retains macromolecular matrix while small interfering species are separated from the target fraction. The collected fraction reaches the analytical instrument at a lower matrix load, which protects the column and detector and improves sensitivity.

Do I need to pack the GPC column myself?

No. The GPC1000 ships with a standard stainless steel GPC column that is supplied packed, and the GPC600 models purify on a high-efficiency stainless steel column. Eliminating manual packing saves operator time and reduces the solvent consumed during column preparation.

Can GPC cleanup connect to concentration equipment?

Yes. GPC1000 loading and collection racks are designed to work with solid-phase extraction and concentration products, and the GPC600 UP and GPC600 mini collection bottles connect to parallel concentration or rotary evaporation without transferring the sample. GPC600 mini provides two rotary evaporator bottle positions that alternate.